Gene information
Official symbol CCN2
Official full name cellular communication network factor 2
Gene type protein-coding gene
Chromosome6q23.2
Alias symbolIGFBP8
Previous symbolCTGF
Gene familyCellular communication network factors
Resources
Entrez Gene 1490
HGNC HGNC:2500
Ensembl ENSG00000118523
Vega OTTHUMG00000015573
UCSC uc003qcz.4
GO terms: 127 records
GO Description Category LogP Number of genes Detail
GO:0001101 response to acid chemical GO Biological Processes -10.2965313 26 More
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001503 ossification GO Biological Processes -16.3087139 28 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0005938 cell cortex GO Cellular Components -2.49954036 24 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006942 regulation of striated muscle contraction GO Biological Processes -11.0877013 23 More
GO:0007160 cell-matrix adhesion GO Biological Processes -9.58867374 15 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007229 integrin-mediated signaling pathway GO Biological Processes -5.80936917 16 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010714 positive regulation of collagen metabolic process GO Biological Processes -7.35623750 7 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010950 positive regulation of endopeptidase activity GO Biological Processes -13.2452311 34 More
GO:0010952 positive regulation of peptidase activity GO Biological Processes -14.1524623 37 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030198 extracellular matrix organization GO Biological Processes -21.4880730 33 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031589 cell-substrate adhesion GO Biological Processes -10.7590108 32 More
GO:0031960 response to corticosteroid GO Biological Processes -20.1789519 26 More
GO:0032231 regulation of actin filament bundle assembly GO Biological Processes -4.42971140 15 More
GO:0032233 positive regulation of actin filament bundle assembly GO Biological Processes -4.83092272 7 More
GO:0032330 regulation of chondrocyte differentiation GO Biological Processes -3.54364153 9 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032872 regulation of stress-activated MAPK cascade GO Biological Processes -11.6818048 20 More
GO:0032874 positive regulation of stress-activated MAPK cascade GO Biological Processes -9.63549885 15 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032965 regulation of collagen biosynthetic process GO Biological Processes -13.1192794 17 More
GO:0032967 positive regulation of collagen biosynthetic process GO Biological Processes -7.48167444 7 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035988 chondrocyte proliferation GO Biological Processes -3.34912948 3 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0043062 extracellular structure organization GO Biological Processes -21.4370160 33 More
GO:0043200 response to amino acid GO Biological Processes -9.16129691 23 More
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -11.0338596 16 More
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO Biological Processes -14.7594418 39 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0044344 cellular response to fibroblast growth factor stimulus GO Biological Processes -7.12681878 10 More
GO:0045229 external encapsulating structure organization GO Biological Processes -21.3355594 33 More
GO:0045823 positive regulation of heart contraction GO Biological Processes -10.6953794 15 More
GO:0045862 positive regulation of proteolysis GO Biological Processes -17.3242033 33 More
GO:0045933 positive regulation of muscle contraction GO Biological Processes -10.2635447 16 More
GO:0045989 positive regulation of striated muscle contraction GO Biological Processes -6.22004109 7 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046330 positive regulation of JNK cascade GO Biological Processes -6.26494407 10 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0048705 skeletal system morphogenesis GO Biological Processes -7.04838258 29 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0051216 cartilage development GO Biological Processes -10.5011549 17 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051492 regulation of stress fiber assembly GO Biological Processes -3.91249954 13 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0051496 positive regulation of stress fiber assembly GO Biological Processes -3.27167533 5 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0055117 regulation of cardiac muscle contraction GO Biological Processes -9.51337974 19 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060452 positive regulation of cardiac muscle contraction GO Biological Processes -7.34622031 5 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0061035 regulation of cartilage development GO Biological Processes -4.43006301 12 More
GO:0061448 connective tissue development GO Biological Processes -12.1108226 21 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070302 regulation of stress-activated protein kinase signaling cascade GO Biological Processes -11.5600448 20 More
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO Biological Processes -9.54226030 15 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0070542 response to fatty acid GO Biological Processes -13.2686457 21 More
GO:0070588 calcium ion transmembrane transport GO Biological Processes -2.54626507 17 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071774 response to fibroblast growth factor GO Biological Processes -7.87961599 11 More
GO:0072593 reactive oxygen species metabolic process GO Biological Processes -9.21564496 21 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097553 calcium ion transmembrane import into cytosol GO Biological Processes -4.27502414 13 More
GO:0110020 regulation of actomyosin structure organization GO Biological Processes -4.68299748 15 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903524 positive regulation of blood circulation GO Biological Processes -11.6803256 16 More
GO:2000116 regulation of cysteine-type endopeptidase activity GO Biological Processes -14.4496812 41 More
GO:2001056 positive regulation of cysteine-type endopeptidase activity GO Biological Processes -11.1582582 17 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa04371 Apelin signaling pathway KEGG Pathway -6.49715749 12 More
hsa04390 Hippo signaling pathway KEGG Pathway -3.46529255 17 More
Drug-Gene interaction
view
Related drugs: 19 records
Drug name Interaction type Source PMID View
2-methoxyestradiol NCI 18292194 view
acridine NCI 16950763 view
androstanolone NCI 11181522 view
curcumin NCI 16306131 view
digoxin NCI 12691286 view
enalapril NCI 18812665 view
estradiol NCI 17210741 view
inositol NCI 15560785 view
insulin NCI 11956149 view
liothyronine sodium NCI 11250650 view
ocaperidone TTD view
pamrevlumab inhibitor TdgClinicalTrialChemblInteractions view
prasterone NCI 15675949 view
propranolol NCI 12691286 view
ramipril NCI 15128880 view
spironolactone NCI 17602195 view
staurosporine NCI 15053922 view
thrombin NCI 10952976 view
vitamin e NCI 12023009 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
CCN family member 2 proteomics myocardial infarction[diagnosis] myocardial infarction Hunt KJ et al. Diabetes Care. 2018
CCN family member 2 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Diao J et al. Acta Cardiol Sin. 2019
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